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![The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist | Journal of Medicinal Chemistry](https://i0.wp.com/pubs.acs.org/cms/10.1021/jm3009103/asset/images/large/jm-2012-009103_0017.jpeg?ssl=1)
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